Supachoke Mangmool

ศุภโชค มั่งมูล

Professor
supachoke.man@mahidol.ac.th
Education

Ph.D. (Pharmaceutical Sciences), Kyushu University, Japan

Current Research
  • Molecular Pharmacology
  • Cardiovascular Pharmacology
  • G protein-coupled receptor signaling pathway
Publications
  • Sudi SB, Tanaka T, Oda S, Nishiyama K, Nishimura A, Sunggip C, Mangmool S, et al. TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy. Sci Rep. 2019 Jul 5;9(1):9785.
  • Sato VH, Sungthong B, Rinthong PO, Nuamnaichati N, Mangmool S, Chewchida S, Sato H. Pharmacological effects of Chatuphalatika in hyperuricemia of gout. Pharm Biol. 2018 Dec;56(1):76-85.
  • Mangmool S, Parichatikanond W, Kurose H. Therapeutic targets for treatment of heart failure: Focus on GRKs and β-arrestins affecting βAR signaling. Front Pharmacol. 2018 Nov 27;9:1336.
  • Parichatikanond W, Nishimura A, Nishida M, Mangmool S. Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells. J Pharmacol Sci. 2018 Nov;138(3):184-91.
  • Phosri S, Bunrukchai K, Parichatikanond W, Sato VH, Mangmool S. Epac is required for exogenous and endogenous stimulation of adenosine A2B receptor for inhibition of angiotensin II-induced collagen synthesis and myofibroblast differentiation. Purinergic Signal. 2018 Jun;14(2):141-56.
  • Sunggip C, Shimoda K, Oda S, Tanaka T, Nishiyama K, Mangmool S, et al. TRPC5-eNOS axis negatively regulates ATP-Iinduced cardiomyocyte hypertrophy. Front Pharmacol. 2018 May 22;9:523.
  • Charoenpitakchai M, Wiwatwarayos K, Jaisupa N, Rusmili MRA, Mangmool S, Hodgson WC, et al. Non-neurotoxic activity of Malayan krait (Bungarus candidus) venom from Thailand. J Venom Anim Toxins Incl Trop Dis. 2018 Mar 9;24:9.
  • Nuamnaichati N, Sato VH, Moongkarndi P, Parichatikanond W, Mangmool S. Sustained β-AR stimulation induces synthesis and secretion of growth factors in cardiac myocytes that affect on cardiac fibroblast activation. Life Sci. 2018 Jan 15;193:257-69.
  • Numaga-Tomita T, Oda S, Shimauchi T, Nishimura A, Mangmool S, Nishida M. TRPC3 channels in cardiac fibrosis. Front Cardiovasc Med. 2017 Sep 7;4:56.
  • Phosri S, Arieyawong A, Bunrukchai K, Parichatikanond W, Nishimura A, Nishida M, Mangmool S. Stimulation of adenosine A2B receptor inhibits endothelin-1-induced cardiac fibroblast proliferation and α-smooth muscle actin synthesis through the cAMP/Epac/PI3K/Akt-signaling pathway. Front Pharmacol. 2017 Jun 30;8:428.
  • Mangmool S, Denkaew T, Parichatikanond W, Kurose H. β-Adrenergic receptor and insulin resistance in the heart. Biomol Ther (Seoul). 2017 Jan 1;25(1):44-56.
  • Watson LJ, Alexander KM, Mohan ML, Bowman AL, Mangmool S, Xiao K, et al. Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation. Cell Signal. 2016 Oct;28(10):1580-92.
  • Kurose H, Mangmool S. Myofibroblasts and inflammatory cells as players of cardiac fibrosis. Arch Pharm Res. 2016 Aug;39(8):1100-13.
  • Jittikoon J, Mahasirimongkol S, Charoenyingwattana A, Chaikledkaew U, Tragulpiankit P, Mangmool S, et al. Comparison of genetic variation in drug ADME-related genes in Thais with Caucasian, African and Asian HapMap populations. J Hum Genet. 2016 Feb;61(2):119-27.
  • Anantachoke N, Lomarat P, Praserttirachai W, Khammanit R, Mangmool S. Thai fruits exhibit antioxidant activity and induction of antioxidant enzymes in HEK-293 cells. Evid Based Complement Alternat Med. 2016;2016:6083136.
  • Mangmool S, Denkaew T, Phosri S, Pinthong D, Parichatikanond W, Shimauchi T, Nishida M. Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner. Mol Endocrinol. 2016 Jan;30(1):118-32.
  • Phanthong P, Phumal N, Chancharunee S, Mangmool S, Anantachoke N, Bunyapraphatsara N. Biological activity of Dolichandrone serrulata flowers and their active components. Nat Prod Commun. 2015 Aug;10(8):1387-90.
  • Vongsak B, Mangmool S, Gritsanapan W. Antioxidant activity and induction of mRNA expressions of antioxidant enzymes in HEK-293 cells of Moringa oleifera leaf extract. Planta Med. 2015 Aug;81(12-13):1084-9.
  • Mangmool S, Hemplueksa P, Parichatikanond W, Chattipakorn N. Epac is required for GLP-1R-mediated inhibition of oxidative stress and apoptosis in cardiomyocytes. Mol Endocrinol. 2015 Apr;29(4):583-96.
  • Anantachoke N, Kitphati W, Mangmool S, Bunyapraphatsara N. Polyphenolic compounds and antioxidant activities of the leaves of Glochidion hypoleucumNat Prod Commun. 2015 Mar;10(3):479-82.
  • Kasemwattanaroj P, Moongkarndi P, Pattanapanyasat K, Mangmool S, Rodpai E, Samer J, et al. Immunomodulatory activities of alpha-mangostin on peripheral blood mononuclear cells. Nat Prod Commun. 2013 Sep;8(9):1257-60.
  • Chittasupho C, Jaturanpinyo M, Mangmool S. Pectin nanoparticle enhances cytotoxicity of methotrexate against HepG2 cells. Drug Deliv. 2013;20(1):1-9.
  • Nakaya M, Chikura S, Watari K, Mizuno N, Mochinaga K, Mangmool S, Koyanagi S, et al. Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways. J Biol Chem. 2012 Oct 12;287(42):35669-77.
  • Parichatikanond W, Pinthong D, Mangmool S. Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin. Planta Med. 2012 Oct;78(15):1626-32.
  • Mangmool S, Kurose H. G(i/o) protein-dependent and -independent actions of Pertussis Toxin (PTX). Toxins (Basel). 2011 Jul;3(7):884-99.
  • Mangmool S, Shukla AK, Rockman HA. beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation. J Cell Biol. 2010 May 3;189(3):573-87.
  • Yoo B, Lemaire A, Mangmool S, Wolf MJ, Curcio A, Mao L, Rockman HA. Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1377-86.
  • Mangmool S, Haga T, Kobayashi H, Kim KM, Nakata H, Nishida M, Kurose H. Clathrin required for phosphorylation and internalization of beta2-adrenergic receptor by G protein-coupled receptor kinase 2 (GRK2). J Biol Chem. 2006 Oct 20;281(42):31940-9.
  • Nishida M, Tanabe S, Maruyama Y, Mangmool S, Urayama K, Nagamatsu Y, et al. G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes. J Biol Chem. 2005 May 6;280(18):18434-41.