Supachoke Mangmool

ศุภโชค มั่งมูล

Professor
+662-201-5508
+662-354-7157
supachoke.man@mahidol.ac.th
Education

Ph.D. (Pharmaceutical Sciences), Kyushu University, Japan

Current Research
  • Molecular Pharmacology
  • Cardiovascular Pharmacology
  • G protein-coupled receptor signaling pathway
Publications
  • Anantachoke N, Duangrat R, Sutthiphatkul T, Ochaikul D, Mangmool S. Kombucha beverages produced from fruit, vegetables, and plants: A review on their pharmacological activities and health benefits. Foods. 2023;12:1818. Doi: 10.3390/foods12091818
  • Duangrat R, Parichatikanond W, Mangmool S. Dual blockade of TGF-β receptor and endothelin receptor synergistically inhibits angiotensin II-induced myofibroblast differentiation: Role of AT1R/Gαq-mediated TGF-β1 and ET-1 signaling. Int J Mol Sci.2023;24:6972. Doi: 10.3390/ ijms24086972
  • Likitnukul S, Thammacharoen S, Sriwatananukulkit O, Duangtha C, Hemstapat R, Sunrat C, Mangmool S, Pinthong D. Short-term growth hormone administration mediates hepatic fatty acid uptake and de novo lipogenesis gene expression in obese rats. Biomedicines. 2023;11(4):1050. Doi: 10.3390/biomedicines11041050
  • Duangrat R, Parichatikanond W, Likitnukul S, Mangmool S. Endothelin-1 induces cell proliferation and myofibroblast differentiation through the ETAR/Gαq/ERK signaling pathway in human cardiac fibroblasts. Int J Mol Sci.2023;24(5):4475. Doi: 10.3390/ ijms24054475
  • Sutthiphatkul T, Mangmool S, Rungjindamai N, Ochaikul D. Characteristics and antioxidant activities of kombucha from black tea and roselle by a mixed starter culture. Curr Appl Sci Technol. 2023:23:4. Doi: 10.55003/cast.2022.04.23.002
  • Pandey S, Madreiter-Sokolowski CT, Mangmool S, Parichatikanond, W. High glucose-induced cardiomyocyte damage involves interplay between endothelin ET-1/ETA/ETB receptor and mTOR Pathway. Int J Mol Sci. 2022; 23:13816. Doi: 10.3390/ ijms232213816
  • Duangrat R, Parichatikanond W, Morales NP, Pinthong D, Mangmool S. Sustained AT1R stimulation induces upregulation of growth factors in human cardiac fibroblasts via Gαq/TGF-β/ ERK signaling that influences myocyte hypertrophy. Eur J Pharmacol. 2022;937:175384. Doi: 10.1016/j.ejphar.2022.175384.
  • Oda S, Nishiyama K, Furumoto Y, Yamaguchi Y, Nishimura A, Tang X, Kato Y, Numaga-tomita T, Kaneko T, Mangmool S, Kuroda T, Okubo R, Sanbo M, Hirabayashi M, Sato Y, Nakagawa Y, Kuwahara K, Nagata R, Iribe G, Mori Y, Nishida M. Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors. Nat Commun. 2022;13:6374. doi: 10.1038/s41467-022-34194-9
  • Mangmool S, Kyaw ETH, Nuamnaichati N, Pandey S, Parichatikanond W. Stimulation of adenosine A1 receptor prevents oxidative injury in H9c2 cardiomyoblasts: Role of Gbg-mediated Akt and ERK1/2 signaling. Toxicol Appl Pharmacol. 2022;451:116175. doi: 1016/j.taap.2022.116175
  • Nuamnaichati N, Parichatikanond W, Mangmool S. Cardioprotective effects of glucagon-like peptide-1 (9-36) against oxidative injury in H9c2 cardiomyoblasts: Potential role of the PI3K/Akt/NOS pathway. J Cardiovasc Pharmacol. 2022;79(1):e50-e63.
  • Mangmool S, Limpichai C, Han KK, Reutrakul V, Anantachoke N. Anti-inflammatory effects of Mitrephora sirikitiae leaf extract and isolated lignans in RAW 264.7 cells. Molecules. 2022;27(10):3313. doi: 3390/molecules27103313
  • Auychaipornlert S, Lawanprasert PP, Piriyaprasarth S, Sithisarn P, Mangmool S. Design of turmeric rhizome extract nano-formula for delivery to cancer cells. 2022;27:896. https://doi.org/10.3390/ molecules27030896
  • Komaikul J, Mangmool S, Putalun W, Kitisripanya T. Preparation of readily-to-use stilbenoids extract from Morus alba callus using a natural deep eutectic solvent. Cosmetics. 2021;8:91. doi: 10.3390/cosmetics8030091
  • Parichatikanond W, Kyaw ETH, Madreiter-Sokolowski CT, Mangmool S. BRET-based assay to specifically monitor β2AR/GRK2 interaction and β-arrestin2 conformational change upon βAR stimulation. Method Cell Biol. 2021;166:67-81. doi: 10.1016/bs.mcb.2021.06.005
  • Wongthai N, Tanticharakunsiri W, Mangmool S, Ochaikul D. Characteristics and antioxidant activity of royal lotus pollen, butterfly pea flower, and oolong tea kombucha beverages. Asia Pac J Sci Technol. 2021;26(4):APST-26-04-17. doi: 10.14456/apst.2021.47
  • Mangmool S, Kunpukpong I, Kitphati W, Anantachoke N. Antioxidant and anticholinesterase activities of extracts and phytochemicals of Syzygium antisepticum Molecules. 2021;26:3295. doi: 10.3390/molecules26113295.
  • Thongra-ar K, Rojsanga P, Chewchinda S, Mangmool S, Sithisarn P. Antioxidant, α-glucosidases and α-amylase inhibitory activities of Persicaria odorata. CMUJ Nat Sci. 2021;20(3): e2021051.
  • Pothongsrisit S, Arunrungvichian K, Hayakawa Y, Sritularak B, Mangmool S, Pongrakhananon V. Erianthridin suppresses non-small-cell lung cancer cell metastasis through inhibition of Akt/mTOR/p70 S6K signaling pathway. Sci Rep. 2021;11:6618. org/10.1038/s41598-021-85675-8
  • Wint NY, Han KK, Yamprayoonswat W, Ruangsuj P, Mangmool S, Promptmas C, Yasawong M. A novel nucleic lateral flow assay for screening phaR-containing Bacillus spp. J Microbiol Biotechnol. 2021;31(1):123-9.
  • Tanticharakunsiri W, Mangmool S, Wongsariya K, Ochaikul D. Characteristics and upregulation of antioxidant enzymes of kitchen mint and oolong tea kombucha beverages. J Food Biochem. 2021;45(1):e13574. doi: 10.1111/jfbc.13574
  • Dechwongya P, Limpisood S, Boonnak N, Mangmool S, Takeda-Morishita M, Kulsirirat T, Rukthong P, Sathirkul K. The intestinal efflux transporter inhibition activity of xanthones from Mangosteen pericarp: An in silico, in vitro and ex vivo approach. Molecules. 2020;25:5877. doi: 10.3390/molecules25245877.
  • Han KK, Mangmool S, Sathirakul K, Chansiri K, Jeamsaksiri W, Yasawong M. Development of ImmunoFET biosensor for detection of 3-nitrotyrosine. Thai J Pharm Sci. 2020;44(3):159-67.
  • Nuamnaichati N, Mangmool S, Chattipakorn N, Parichatikanond W. Stimulation of GLP-1 receptor inhibits methylglyoxal-induced mitochondrial dysfunctions in H9c2 cardiomyoblasts: Potential role of Epac/PI3K/Akt pathway. Front Pharmacol. 2020;11:805. doi: 10.3389/fphar. 2020.00805
  • Parichatikanond W. Luangmonkong T, Mangmool S, Kurose H. Therapeutic targets for the treatment of cardiac fibrosis and cancer: focusing on TGF-β Front Cardiovasc Med. 2020;7:34. doi:10.3389/fcvm.2020.00034
  • Ondee S, Sithisarn P, Mangmool S, Rojsanga P. Chemical standardization and anti-proliferative activity of Ardisia elliptica fruit against the HCT116 human colon cancer cell line. Molecules. 2020;25:1023. doi: 10.3390/molecules25051023
  • Nishida M, Tanaka T, Mangmool S, Nishiyama K, Nishimura A. Canonical transient receptor potential channels and vascular smooth muscle cell plasticity. J Lipid Atheroscler. 2020;9(1):124-39.
  • Sudi SB, Tanaka T, Oda S, Nishiyama K, Nishimura A, Sunggip C, Mangmool S, et al. TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy. Sci Rep. 2019 Jul 5;9(1):9785.
  • Sato VH, Sungthong B, Rinthong PO, Nuamnaichati N, Mangmool S, Chewchida S, Sato H. Pharmacological effects of Chatuphalatika in hyperuricemia of gout. Pharm Biol. 2018 Dec;56(1):76-85.
  • Mangmool S, Parichatikanond W, Kurose H. Therapeutic targets for treatment of heart failure: Focus on GRKs and β-arrestins affecting βAR signaling. Front Pharmacol. 2018 Nov 27;9:1336.
  • Parichatikanond W, Nishimura A, Nishida M, Mangmool S. Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells. J Pharmacol Sci. 2018 Nov;138(3):184-91.
  • Phosri S, Bunrukchai K, Parichatikanond W, Sato VH, Mangmool S. Epac is required for exogenous and endogenous stimulation of adenosine A2B receptor for inhibition of angiotensin II-induced collagen synthesis and myofibroblast differentiation. Purinergic Signal. 2018 Jun;14(2):141-56.
  • Sunggip C, Shimoda K, Oda S, Tanaka T, Nishiyama K, Mangmool S, et al. TRPC5-eNOS axis negatively regulates ATP-Iinduced cardiomyocyte hypertrophy. Front Pharmacol. 2018 May 22;9:523.
  • Charoenpitakchai M, Wiwatwarayos K, Jaisupa N, Rusmili MRA, Mangmool S, Hodgson WC, et al. Non-neurotoxic activity of Malayan krait (Bungarus candidus) venom from Thailand. J Venom Anim Toxins Incl Trop Dis. 2018 Mar 9;24:9.
  • Nuamnaichati N, Sato VH, Moongkarndi P, Parichatikanond W, Mangmool S. Sustained β-AR stimulation induces synthesis and secretion of growth factors in cardiac myocytes that affect on cardiac fibroblast activation. Life Sci. 2018 Jan 15;193:257-69.
  • Numaga-Tomita T, Oda S, Shimauchi T, Nishimura A, Mangmool S, Nishida M. TRPC3 channels in cardiac fibrosis. Front Cardiovasc Med. 2017 Sep 7;4:56.
  • Phosri S, Arieyawong A, Bunrukchai K, Parichatikanond W, Nishimura A, Nishida M, Mangmool S. Stimulation of adenosine A2B receptor inhibits endothelin-1-induced cardiac fibroblast proliferation and α-smooth muscle actin synthesis through the cAMP/Epac/PI3K/Akt-signaling pathway. Front Pharmacol. 2017 Jun 30;8:428.
  • Mangmool S, Denkaew T, Parichatikanond W, Kurose H. β-Adrenergic receptor and insulin resistance in the heart. Biomol Ther (Seoul). 2017 Jan 1;25(1):44-56.
  • Watson LJ, Alexander KM, Mohan ML, Bowman AL, Mangmool S, Xiao K, et al. Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation. Cell Signal. 2016 Oct;28(10):1580-92.
  • Kurose H, Mangmool S. Myofibroblasts and inflammatory cells as players of cardiac fibrosis. Arch Pharm Res. 2016 Aug;39(8):1100-13.
  • Jittikoon J, Mahasirimongkol S, Charoenyingwattana A, Chaikledkaew U, Tragulpiankit P, Mangmool S, et al. Comparison of genetic variation in drug ADME-related genes in Thais with Caucasian, African and Asian HapMap populations. J Hum Genet. 2016 Feb;61(2):119-27.
  • Anantachoke N, Lomarat P, Praserttirachai W, Khammanit R, Mangmool S. Thai fruits exhibit antioxidant activity and induction of antioxidant enzymes in HEK-293 cells. Evid Based Complement Alternat Med. 2016;2016:6083136.
  • Mangmool S, Denkaew T, Phosri S, Pinthong D, Parichatikanond W, Shimauchi T, Nishida M. Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner. Mol Endocrinol. 2016 Jan;30(1):118-32.
  • Phanthong P, Phumal N, Chancharunee S, Mangmool S, Anantachoke N, Bunyapraphatsara N. Biological activity of Dolichandrone serrulata flowers and their active components. Nat Prod Commun. 2015 Aug;10(8):1387-90.
  • Vongsak B, Mangmool S, Gritsanapan W. Antioxidant activity and induction of mRNA expressions of antioxidant enzymes in HEK-293 cells of Moringa oleifera leaf extract. Planta Med. 2015 Aug;81(12-13):1084-9.
  • Mangmool S, Hemplueksa P, Parichatikanond W, Chattipakorn N. Epac is required for GLP-1R-mediated inhibition of oxidative stress and apoptosis in cardiomyocytes. Mol Endocrinol. 2015 Apr;29(4):583-96.
  • Anantachoke N, Kitphati W, Mangmool S, Bunyapraphatsara N. Polyphenolic compounds and antioxidant activities of the leaves of Glochidion hypoleucumNat Prod Commun. 2015 Mar;10(3):479-82.
  • Kasemwattanaroj P, Moongkarndi P, Pattanapanyasat K, Mangmool S, Rodpai E, Samer J, et al. Immunomodulatory activities of alpha-mangostin on peripheral blood mononuclear cells. Nat Prod Commun. 2013 Sep;8(9):1257-60.
  • Chittasupho C, Jaturanpinyo M, Mangmool S. Pectin nanoparticle enhances cytotoxicity of methotrexate against HepG2 cells. Drug Deliv. 2013;20(1):1-9.
  • Nakaya M, Chikura S, Watari K, Mizuno N, Mochinaga K, Mangmool S, Koyanagi S, et al. Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways. J Biol Chem. 2012 Oct 12;287(42):35669-77.
  • Parichatikanond W, Pinthong D, Mangmool S. Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin. Planta Med. 2012 Oct;78(15):1626-32.
  • Mangmool S, Kurose H. G(i/o) protein-dependent and -independent actions of Pertussis Toxin (PTX). Toxins (Basel). 2011 Jul;3(7):884-99.
  • Mangmool S, Shukla AK, Rockman HA. beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation. J Cell Biol. 2010 May 3;189(3):573-87.
  • Yoo B, Lemaire A, Mangmool S, Wolf MJ, Curcio A, Mao L, Rockman HA. Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1377-86.
  • Mangmool S, Haga T, Kobayashi H, Kim KM, Nakata H, Nishida M, Kurose H. Clathrin required for phosphorylation and internalization of beta2-adrenergic receptor by G protein-coupled receptor kinase 2 (GRK2). J Biol Chem. 2006 Oct 20;281(42):31940-9.
  • Nishida M, Tanabe S, Maruyama Y, Mangmool S, Urayama K, Nagamatsu Y, et al. G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes. J Biol Chem. 2005 May 6;280(18):18434-41.