Porntip Supavilai

Associate Professor
  • B.Sc. (Chemistry) Mahidol University, Thailand
  • M.Sc. (Pharmacology) Mahidol University, Thailand
  • Ph.D. (Cum Laude, Pharmacy) University of Basel, Switzerland
Current Research
  • Molecular pharmacology
  • Neuropharmacology
  • Neuroscience
  • Pharmacogenomics
  • Pharmacology of medicinal plants
  • Pongthanaracht N, Yanarojana S, Pinthong DUnchern SThithapandha AAssantachai PSupavilai PAssociation between butyrylcholinesterase k variant and mild cognitive impairment in the Thai community-dwelling patients. Clinical Interventions in Aging 2017; 12:897-901.
  • Sensorn I, Sirachainan E, Chamnanphon M, Pasomsub E, Trachu N, Supavilai P, et al. Association of CYP3A4/5, ABCB1 and ABCC2 polymorphisms and clinical outcomes of Thai breast cancer patients treated with tamoxifen. Pharmgenomics Pers Med. 2013;6:93-8.
  • Thampithak A, Jaisin Y, Meesarapee B, Chongthammakun S, Piyachaturawat P, Govitrapong P, Supavilai P, Sanvarinda Y. Transcriptional regulation of iNOS and COX-2 by a novel compound from Curcuma comosa in lipopolysaccharide-induced microglial activation. Neurosci Lett. 2009;462(2):171-5.
  • Pinweha S, Wanikiat P, Sanvarinda Y, Supavilai P. The signaling cascades of Ganoderma lucidum extracts in stimulating non-amyloidogenic protein secretion in human neuroblastoma SH-SY5Y cell lines. Neurosci Lett. 2008;448(1):62-6.
  • Hanchar HJ, Chutsrinopkun P, Meera P, Supavilai P, Sieghart W, Wallner M, et al. Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors. Proc Natl Acad Sci U S A. 2006;103(22):8546-51.
  • Chiba Y, Srisodsai A, Supavilai P, Kimura S. Interleukin-5 reduces the expression of uteroglobin-related protein (UGRP) 1 gene in allergic airway inflammation. Immunol Lett. 2005;97(1):123-9.
  • Asano S, Park JE, Sakchaisri K, Yu LR, Song S, Supavilai P, et al. Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast. EMBO J. 2005;24(12):2194-204.
  • Muangman V, Thithapandha A, Yoovathaworn K, Supavilai P, Arunnopparat W, Sriwatanakul K. A study on diuretic effects of Pluchea indica in man. Thai J Uro. 1998;19: 116–28.
  • Shapiro G, Floersheim P, Boelsterli J, Amstutz R, Bolliger G, Gammenthaler H, Gmelin G, Supavilai P, Walkinshaw M. Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor. J Med Chem. 1992;35(1):15-27.
  • Pombo-Villar E, Wiederhold KH, Mengod G, Palacios JM, Supavilai P, Boddeke HW. Stereoisomerism and muscarinic receptor agonists: synthesis and effects of the stereoisomers of 3-[5-(3-amino-1,2,4-oxadiazol)yl]-1- azabicyclo[2.2.1]heptane. Eur J Pharmacol. 1992;226(4):317-25.
  • Enz A, Shapiro G, Supavilai P, Boddeke HW. SDZ ENS 163 is a selective M1 agonist and induces release of acetylcholine. Naunyn Schmiedebergs Arch Pharmacol. 1992;345(3):282-7.
  • Pombo-Villar E, Supavilai P, Weber HP, Boddeke HWGM. 6-Carboxymethyl-2-azabicyclo [2,2,1]heptane enantiomers: muscarinic activities of rigid analogues of arecoline. Bioorg Med Chem Lett. 1992;2:501-4.
  • Shapiro G, Floersheim P, Amstutz R, Boddeke H, Bolliger G, Cottens S, Enz A, Gmelin G, Gull P, Supavilai P. Muscarinic agonist SAR of azaspirodioxolanes. Bioorg Med Chem Lett. 1992;2:815-20.
  • Closse A, Supavilai P, Charuchinda C, Camps M, Doctor H, Wanner A, et al. CV 205-502, a non-catechol dopaminergic agonist for the selective labeling of dopamine D2 receptor in vitro and in vivo. In: Central and peripheral dopamine receptors: Biochemistry and Pharmacology. Padova: Liviana press. 1988:205-13.
  • Karobath M, Coward D, Enz A, Haefliger W, Jaton A, Markstein R, Palacios JM, Shearman G,Supavilai P, et al. Functional effects of partial D2 dopamine receptor agonists. In: Progress in catecholamine research. Part B: Central Aspects. Liss, Inc. 1988:19-26.
  • Charuchinda C, Supavilai P, Karobath M, Palacios JM. Dopamine D2 receptors in the rat brain: autoradiographic visualization using a high-affinity selective agonist ligand. J
    . 1987;7(5):1352-60.
  • Enz A, Kelly PH, Palacios JM, Supavilai P, Wiederhold KH. Pharmacological and behavioral small effects of pilocarpine. In : Proceedings of the international symposium on muscarinic cholinergic mechanisms. London: Freund. 1987:120-4.
  • Karobath M and Supavilai P. Depressant drug interactions with benzodiazepine/GABA receptors. In: Benzodiazepine GABA receptors and chloride channels: structures and functional properties. Receptor Biochemistry and Methodology. 1986:185-93.
  • Supavilai P, Cortes R, Palacios JM, Karobath M. Evidence for the existence of a GABA/ chloride ion channel complex in mammalian brain with does not contain benzodiazepine receptor sites. In: Neuromodulation of central and peripheral transmitter functions. New York: Ravan Press. 1986:453-7.
  • Supavilai P, Karobath M. Modulation of acetylcholine release from rat striatal slices by the GABA/benzodiazepine receptor complex. Life Sci. 1985;36(5):417-26.
  • Supavilai P, Cortes R, Palacios JM, Karobath M. Calcium entry blockers: autoradiographic mapping of their binding sites in rat brain. Prog Brain Res. 1985;63:89-95.
  • Karobath M, Supavilai P. Interaction of benzodiazepine receptor agonists and inverse agonists with the GABA benzodiazepine receptor complex. Pharmacol Biochem Behav.  1985;23(4):671-4.
  • Supavilai P, Karobath M. The interaction of [3H]PY 108-068 and of [3H]PN 200-110 with calcium channel binding sites in rat brain. J Neural Transm. 1984;60(3-4):149-67.
  • Supavilai P, Karobath M. [35S]-t-butylbicyclophosphorothionate binding sites are constituents of the gamma-aminobutyric acid benzodiazepine receptor complex. J Neurosci. 1984;4(5):1193-200.
  • Cortes R, Supavilai P, Karobath M, Palacios JM. Calcium antagonist binding sites in the rat brain: quantitative autoradiographic mapping using the 1,4-dihydropyridines [3H]PN 200-110 and [3H]PY 108-068. J Neural Transm. 1984;60(3-4):169-97.
  • Borea PA, Supavilai P, Karobath M. Effect of GABA and photoaffinity labelling on the affinity of drugs for benzodiazepine receptors in membranes of the cerebral cortex of five-day-old rats. Biochem Pharmacol. 1984;33(1):165-8.
  • Supavilai P, Karobath M. Differential modulation of [35S]TBPS binding by the occupancy of benzodiazepine receptors with its ligands. Eur J Pharmacol. 1983;91(1):145-6.
  • Karobath M, Supavilai P, Borea PA. Distinction of benzodiazepine receptor agonists and inverse agonists by binding studies in vitro. Adv Biochem Psychopharmacol.  1983;38:37-45.
  • Cortes R, Supavilai P, Karobath M, Palacios JM. The effects of lesions in the rat hippocampus suggest the association of calcium channel blocker binding sites with specific neuronal population. Neurosci Lett. 1983;42(3):249-54.
  • Borea PA, Supavilai P, Karobath M. Differential modulation of etazolate or pentobarbital enhanced [3H] muscimol binding by benzodiazepine agonists and inverse agonists. Brain Res. 1983;280(2):383-6.
  • Karobath M, Supavilai P, Plachesta P, Sieghart W. Interactions of anxiolytic drugs with benzodiazepine receptors. In: Recent advances in neuropsychopharmacology depressant and CNS convulsants. Neurochem Internet. 1982;4:259-68.
  • Sieghart W, Supavilai P, Karobath M. Investigation of brain benzodiazepine receptors using flunitrazepam as a photoaffinity label. In: Pharmacology of benzodiazepine. London: Macmillian Press Ltd. 1982:141-8.
  • Supavilai P, Mannonen A, Karobath M. Modulation of GABA binding sites by CNS depressants and CNS convulsants. Neurochem Int. 1982;4(4):259-68.
  • Supavilai P, Mannonen A, Collins JF, Karobath M. Anion-dependent modulation of [3H]muscimol binding and of GABA-stimulated [3H]flunitrazepam binding by picrotoxin and related CNS convulsants. Eur J Pharmacol. 1982;81(4):687-91.
  • Sieghart W, Drexler G, Supavilai P, Karobath M. Properties of benzodiazepine receptors in rat retina. Exp Eye Res.  1982;34(6):961-7.
  • Karobath M, Supavilai P. Distinction of benzodiazepine agonists from antagonists by photoaffinity labelling of benzodiazepine receptors in vitro. Neurosci Lett. 1982;31(1):65-9.
  • Supavilai P, Karobath M. In vitro modulation by avermectin B1a of the GABA/benzodiazepine receptor complex of rat cerebellum. J Neurochem. 1981;36(3):798-803.
  • Supavilai P, Karobath M. Action of pyrazolopyridines as modulators of [3H]flunitrazepam binding to the gaba/benzodiazepine receptor complex of the cerebellum. Eur J Pharmacol. 1981;70(2):183-93.
  • Sieghart W, Placheta P, Supavilai P, Karobath M. GABA receptor associated drug receptors.Adv Biochem Psychopharmacol. 1981;26:121-8.
  • Karobath M, Drexler G, Supavilai P. Modulation by picrotoxin and IPTBO of 3H-flunitrazepam binding to the GABA/benzodiazepine receptor complex of rat cerebellum. Life Sci. 1981;28(3):307-13.
  • Karobath M, Supavilai P, Placheta P, Sieghart W. Modulation of brain GABA/ benzodiazepine receptor complex by the pyrazolopyridines SQ20009 and SQ65396. In: Drug receptors in central nervous system. New York, Wiley. 1980:429-38.
  • Supavilai P, Karobath M. Interaction of SQ 20009 and GABA-like drugs as modulators of benzodiazepine receptor binding. Eur J Pharmacol. 1980;62(2-3):229-33.
  • Supavilai P, Karobath M. Heterogeneity of benzodiazepine receptors in rat cerebellum and hippocampus. Eur J Pharmacol. 1980;64(1):91-3.
  • Supavilai P, Karobath M. Ethanol and other CNS depressants decrease GABA synthesis in mouse cerebral cortex and cerebellum in vivo. Life Sci. 1980;27(12):1035-40.
  • Supavilai P, Karobath M. The effect of temperature and chloride ions on the stimulation of [3H]flunitrazepam binding by the muscimol analogues THIP and piperidine-4-sulfonic acid. Neurosci Lett. 1980;19(3):337-41.
  • Supavilai P, Karobath M. Stimulation of benzodiazepine receptor binding by SQ 20009 is chloride-dependent and picrotoxin-sensitive. Eur J Pharmacol. 1979;60(1):111-3.
  • Sadavongvivad C and Supavilai P. Three monohydroxy-coumarines from Alyxia lucida Phytochemistry. 1977;16:1451.