Nattinee Jantaratnotai

ณัฎฐิณี จันทรรัตโนทัย

M.Sc. Program Director
Associate Professor
  • B.Sc. (Medical Science) Mahidol University, Thailand
  • M.D. (Medicine) Siriraj Hospital, Mahidol University, Thailand
  • Ph.D. (Pharmacology), Mahidol University, Thailand
  • Dip. (Psychiatry), Ramathibodi Hospital, Mahidol University, Thailand
Current Research
  • Neuroprotective aspects (anti-oxidation and anti-inflammatory) of Thai medicinal plants
  • The pathogenesis of neurodegenerative diseases
  • Aromatherapy in psychiatic disorders
  • Jiamvoraphong N, Jantaratnotai N, Sanvarinda P, Tuchinda P, Piyachaturawat P, Thampithak A, Sanvarinda P*. Concurrent suppression of NF-κB, p38 MAPK and reactive oxygen species formation underlies the effect of a novel compound isolated from Curcuma comosa Roxb. in LPS-activated microglia. J Pharm Pharmacol 2017 Jul;69(7):917-24.
  • Jantaratnotai N, Mosikanon K, Lee Y, McIntyre R. The interface of depression and obesity. Obes Res Clin Pract 2017;11:1—10.
  • Vattanarongkup J, Piyachaturawat P, Tuchinda P, Sanvarinda P, Sanvarinda Y, Jantaratnotai N. Protective effects of a diarylheptanoid from Curcuma comosa against hydrogen peroxide-induced astroglial cell death. Planta Med. 2016; 82(17):1456-1462.
  • Ryu JK, Cho T, Choi HB, Jantaratnotai N, McLarnon JG*. Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer’s disease. J Neuroinflammation. 2015;9(12):144.
  • Pitaksalee R, Sanvarinda Y, Sinchai T, Sanvarinda P, Thampithak A, Jantaratnotai N, et al. Autophagy Inhibition by Caffeine increases toxicity of methamphetamine in SH-SY5Y neuroblastoma cell line. . Neurotox Res. 2015 ;27(4):421-9.
  • Ryu JK, Little JP, Klegeris A, Jantaratnotai N, McLarnon JG. Actions of the anti-angiogenic compound angiostatin in an animal model of Alzheimer’s disease. Curr Alzheimer Res. 2013;10(3):252-60.
  • Jantaratnotai N, Utaisincharoen P, Sanvarinda P, Thampithak A, Sanvarinda Y. Phytoestrogens mediated anti-inflammatory effect through suppression of IRF-1 and pSTAT1 expressions in lipopolysaccharide-activated microglia. Int Immunopharmacol. 2013;17(2):483-8.
  • Jantaratnotai N, Ling A, Cheng J, Schwab C, McGeer PL, McLarnon JG. Upregulation and expression patterns of the angiogenic transcription factor ets-1 in Alzheimer’s disease brain.J Alzheimers Dis.  2013;37(2):367-77.
  • Jantaratnotai N, McGeer PL, McLarnon JG. Mechanisms of Mg2+ inhibition of BzATP-dependent Ca2+ responses in THP-1 monocytes. Brain Res. 2012;1442:1-8.
  • Ryu JK, Jantaratnotai N, Serrano-Perez MC, McGeer PL, McLarnon JG. Block of purinergic P2X7R inhibits tumor growth in a C6 glioma brain tumor animal model. J Neuropathol Exp Neurol. 2011;70(1):13-22.
  • Lee M, Jantaratnotai N, McGeer E, McLarnon JG, McGeer PL. Mg2+ ions reduce microglial and THP-1 cell neurotoxicity by inhibiting Ca2+ entry through purinergic channels. Brain Res. 2011;1369:21-35.
  • Jantaratnotai N, Ryu JK, Schwab C, McGeer PL, McLarnon JG. Comparison of vascular perturbations in an Aβ-injected animal model and in AD brain. Int J Alzheimers Dis. 2011;2011:918280.
  • Jantaratnotai N, McLarnon JG. Calcium dependence of purinergic subtype P2Y(1) receptor modulation of C6 glioma cell migration. Neurosci Lett. 2011;497(2):80-4.
  • Lee M, Cho T, Jantaratnotai N, Wang YT, McGeer E, McGeer PL. Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases.FASEB J. 2010;24(7):2533-45.
  • Jantaratnotai N, Schwab C, Ryu JK, McGeer PL, McLarnon JG. Converging perturbed microvasculature and microglial clusters characterize Alzheimer disease brain. Curr Alzheimer Res. 2010;7(7):625-36.
  • Ryu JK, Jantaratnotai N, McLarnon JG. Thalidomide inhibition of vascular remodeling and inflammatory reactivity in the quinolinic acid-injected rat striatum. Neuroscience. 2009;163(2):601-8.
  • Jantaratnotai N, Choi HB, McLarnon JG. ATP stimulates chemokine production via a store-operated calcium entry pathway in C6 glioma cells. BMC Cancer. 2009;9:442.
  • Jantaratnotai N, Utaisincharoen P, Piyachaturawat P, Chongthammakun S, Sanvarinda Y. Inhibitory effect of Curcuma comosa on NO production and cytokine expression in LPS-activated microglia. Life Sci. 2006;78(6):571-7.
  • Jantaratnotai N, Ryu JK, Kim SU, McLarnon JG. Amyloid β peptide-induced corpus callosum damage and glial activation in vivo. Neuroreport. 2003;14(11):1429-33.