Krongtong Yoovathaworn

Associate Professor
  • B.Sc. (Pharmacy) Chulalongkorn University, Thailand
  • M.Sc. (Pharmacology) Mahidol University, Thailand
  • Ph.D. (Pharmacology) Mahidol Unviersity, Thailand
Current Research
  • Pharmacogenomics- & gene- environment interactions
  • Pharmacokinetics, toxicokinetics
  • Factors modulating xenobiotic metabolism
  • Safety & efficacy evaluation of drugs and xenobiotics
  • Nanotoxicology
  • Kongseng S, Yoovathaworn K, Wongprasert K, Chunhabundit R, Sukwong P, Pissuwan D. Cytotoxic and inflammatory responses of TiOnanoparticles on human peripheral blood mononuclear cells. J Appl Toxico. 2016, DOI 10.1002/jat.3342.
  • Sukwong P, Somkid K, Kongseng S, Pissuwan D, Yoovathaworn K. Respiratory tract toxicity of titanium dioxide nanoparticles and multi-walled carbon nanotubes on mice after intranasal exposure. Micro & Nano Letters. 2016;11(4):183-7.
  • Tanaviyutpakdee P, Yoovathaworn K, Sirivarasai J, Chanprasertyothin S, Panpunuan P, Petchpoung K, et al. Role of CYP2E1 and NQO1 polymorphisms in oxidative stress derived cancer in Thais with and without dyslipidemia. Asian Biomed. 2015;9(5):601-11.
  • Sirivarasai J, Petchpoung K, Khansakorn N, Yoovathaworn K, Sura S, Kaojarern S. Alteration of oxidative stress biomarkers resulting from environmental exposure to PAHs. Thai Journal of Toxicology. 2015;30(1):60-77.
  • Sirivarasai J,  Kaojarern S,  Chanprasertyothin S,  Panpunuan P,  Petchpoung K,  Tatsaneeyapant A,  Yoovathaworn K,  Sura T,  Kaojarern S,  Sritara P.   Environmental lead exposure, catalase gene, and markers of antioxidant and oxidative stress relation to hypertension: An analysis based on the EGAT study.  Biomed Res Int. 2015; Article number 856319.
  • Wananukul W, Sura T, Yoovathaworn K, Kasiwut N, Ongphiphadhanakul  B.  Impact of vitamin D receptor gene polymorphisms on blood lead levels in Thai lead exposed workers. Asian Biomed. 2012;6(1):43-50.
  • Korprasertthaworn P, Rowland A, Lewis BC, Mackenzie PI, Yoovathaworn K, Miners JO. Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity. Biochem Pharmacol. 2012;84(11):1511-21.
  • Khansakorn N, Wongwit W, Tharnpoophasiam P, Hengprasith B, Suwannatho L, Pethchpoung K, Yoovathaworn K, Chanprasertyothin S, Sura T, Kaojarern S, Sritara P, Sirivarasai J. Impact of GSTM1, GSTT1, GSTP1 polymorphism and environmental lead exposure on oxidative stress biomarkers. Sci Res Essays. 2011;6(31):6540-7.
  • Sirivarasai J, Kaojarern S, Sura T, Yoovathaworn K. Biochemical, environmental, and genetic factors associated with paraoxonase (PON1) activity. Biochem Genet. 2011;49(5-6):364-8.
  • Petchpoung K, Kaojarern S, Yoovathaworn K, Sura T, Sirivarasai J. The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentration in Thai bus drivers. Environ Toxicol Pharmacol. 2011;31(1):160-4.
  • Sirivarasai J , Kaojarern S, Yoovathaworn K, Sura T. Cholinesterase activity, pesticide exposure and health impact in a population exposed to organophosphates.  Int Arch Occup Environ Health. 2009;82:833–42.
  • Korprasertthaworn P, Udomuksorn W, Yoovathaworn K. Three novel single nucleotide polymorphisms of UGT1A9 in a Thai population. Drug Metab Pharmacokinet. 2009;24(5): 482-5.
  • Udomuksorn W, Elliot DJ, Lewis BC, Mackenzie PI, Yoovathaworn K, Miners JO. Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates. Pharmacogenet Genomics. 2007;17(12):1017-29.
  • Sirivarasai J, Kaojarern S, Yoovathaworn K, Sura T. Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects. Chem Biol Interact. 2007;168(3):184-92.
  • Podprasart V, Satayavivad J, Riengrojpitak S, Wilairat P, Wananukul W, Chavalittumrong P, Chivapat S, Yoovathaworn K. No direct hepatotoxic potential following a multiple-low dose paraquat exposure in rat as related to its bioaccumulation. Toxicol Lett. 2007;170(3):193-202.
  • Peamkrasatam S, Sriwatanakul K, Kiyotani K, Fujieda M, Yamazaki H, Kamataki T, Yoovathaworn K. In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais. Drug Metab Pharmacokinet. 2006;21(6):475-84.
  • Kerdpin O, Elliot DJ, Boye SL, Birkett DJ, Yoovathaworn K, Miners JO. Differential contribution of active site residues in substrate recognition sites 1 and 5 to cytochrome P450 2C8 substrate selectivity and regioselectivity. Biochemistry. 2004;43(24):7834-42.
  • Chanyachukul T, Yoovathaworn K, Thongsaard W, Chongthammakun S, Navasumrit P, Satayavivad J. Attenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivo. Toxicol Lett. 2004;150(3):259-69.
  • Boye SL, Kerdpin O, Elliot DJ, Miners JO, Kelly L, McKinnon RA, Bhasker CR, Yoovathaworn K, Birkett DJ. Optimizing bacterial expression of catalytically active human cytochromes P450: comparison of CYP2C8 and CYP2C9. Xenobiotica. 2004;34(1):49-60.
  • Jeenapongsa R, Yoovathaworn K, Sriwatanakul KM, Pongprayoon U, Sriwatanakul K. Anti-inflammatory activity of (E)-1-(3,4-dimethoxyphenyl) butadiene from Zingiber cassumunar Roxb. J Ethnopharmacol. 2003;87(2-3):143-8.
  • Yoovathaworn K, Tangksucharit P, Piamkrasaetham S, Sriwatanakul KM, Thithapandha A, Riengrojpitak S, Chavalittumrong P.  Modulation of chloroform induced toxicity by garlic oil in rats. Toxicology. 2001;164(1-3):165-6.
  • Satayavivad J, Chirapathomsakul D, Lordngern S, Tuntawirun J, Yoovathaworn K, Wanichanon C. Arsenic exposure and histological alterations of pancreas. Toxicology. 2001; 161(1-3):66.
  • Muangman V, Thithapandha A, Yoovathaworn K, Supavilai P, Arunnopparat W, Sriwatanakul K. A study on diuretic effects of Pluchea indica in man. Thai J Uro. 1998;19: 116-28.
  • Makarananda K, Pengpan U, Srisakulthong M, Yoovathaworn K, Sriwatanakul K. Monitoring of aflatoxin exposure by biomarkers. J Toxicol Sci. 1998;23(Supp 2):155-9.
  • Prescott LF, Yoovathaworn K, Makarananda K, Saivises R, Sriwatanakul K. Impaired absorption of paracetamol in vegetarians. Br J Clin Pharmacol. 1993;36(3):237-40.
  • Yoovathaworn K, Sriwatanakul KM, Bariboon P, Sriwatanakul K. Studies to determine tolerability and tin levels in human volunteers consuming high tin canned pineapple.  Toxicol Lett. 1992(Supp).
  • Sriwatanakul KM, Pengpan U, Karunyavanij S, Yoovathaworn K, Sriwanakul K. Human monitoring of aflatoxin exposure in a Thai vegetarian community. Toxicol Lett. 1992(Supp).
  • Miners JO, Lillywhite KJ, Yoovathaworn K, Pongmarutai M, Birkett DJ. Characterization of paracetamol UDP-glucuronosyltransferase activity in human liver microsomes. Biochem Pharmacol. 1990;40(3):595-600.
  • Komthong S, Yoovathaworn K, Thithapandha A. Biphasic effect of methadone on hepatic drug metabolism. Proc Soc Exp Biol Med. 1987;184(1):40-6.
  • Yoovathaworn KC, Sriwatanakul K, Thithapandha A. Influence of caffeine on aspirin pharmacokinetics. Eur J Drug Metab Pharmacokinet. 1986;11(1):71-6.
  • Chawalit K, Sretarugsa P, Thithapandha A. Comparative effects of diabetogenic agents on hepatic drug metabolism. Drug Metab Dispos. 1982;10(1):81-6.