นพวรรณ ภู่มาลา มอราเลส

รองศาสตราจารย์
+662-201-5507
+662-354-7157
noppawan.phu@mahidol.ac.th
Education
  • B.Sc. (Chemistry, First-Class Honour) Mahidol University, Thailand
  • M.Sc. (Pharmacology) Mahidol University, Thailand
  • Ph.D. Kyushu University, Japan
Current Research
  • Research in iron-induced oxidative stress and free radical reactions
  • Application of electron spin resonance (ESR) spectroscopy in biology and medicine
Publications
  • Choengchan N, Mantim T, Inpota P, Nacapricha D, Wilairat P, Jittangprasert P, Waiyawat W, Fucharoen S, Sirankpracha P, Morales NP. Tandem measurements of iron and creatinine by cross injection analysis with application to urine from thalassemic patients. Talanta. 2015;133:52-8.
  • Yatmark P, Morales NP, Chaisri U, Wichaiyo S, Hemstapat W, Srichairatanakool S, et al. Iron distribution and histopathological characterization of the liver and heart of β-thalassemic mice with parenteral iron overload: Effects of deferoxamine and deferiprone.Exp Toxicol Pathol. 2014;66(7):333-43.
  • Meesarapee B, Thampithak A, Jaisin Y, Sanvarinda P, Suksamrarn A, Tuchinda P, Morales NP, Sanvarinda Y. Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells. Phytother Res. 2014;28(4):611-6.
  • Toledo RA, Qin Y, Srikantan S, Morales NP, Li Q, Deng Y, et al. In vivo and in vitro oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas. Endocr Relat Cancer. 2013;20(3):349-59.
  • Angthong C, Morales NP, Sutipornpalangkul W, Khadsongkram A, Pinsornsak P, Pongcharoen B. Can levels of antioxidants in synovial fluid predict the severity of primary knee osteoarthritis: a preliminary study. SpringerPlus. 2013;2:652.
  • Sutipornpalangkul W, Morales NP, Unchern S, Sanvarinda Y, Chantharaksri U, Fucharoen S. Vitamin E supplement improves erythrocyte membrane fluidity of thalassemia: an ESR spin labeling study. J Med Assoc Thai. 2012;95(1):29-36.
  • Rodrat S, Yamanont P, Tankanitlert J, Chantraraksri U, Fucharoen S, Morales NP. Comparison of pharmacokinetics and urinary iron excretion of two single doses of deferiprone in β-thalassemia/hemoglobin E patients. Pharmacology. 2012;90(1-2):88-94.
  • Morales NP, Yamaguchi Y, Murakami K, Kosem N, Utsumi H. Hepatic reduction of carbamoyl-PROXYL in ferric nitrilotriacetate induced iron overloaded mice: an in vivo ESR study. Biol Pharm Bull. 2012;35(7):1035-40.
  • Knechtle B, Morales NP, Gonzalez ER, Gutierrez AA, Sevilla JN, Gomez RA, et al. Effect of a multistage ultraendurance triathlon on aldosterone, vasopressin, extracellular water and urine electrolytes. Scott Med J. 2012;57(1):26-32.
  • Burnichon N, Cascon A, Schiavi F, Morales NP, Comino-Mendez I, Abermil N, et al. MAX mutations cause hereditary and sporadic pheochromocytoma and paraganglioma. Clin Cancer Res. 2012;18(10):2828-37.
  • Sinchai T, Plasen S, Sanvarinda Y, Jaisin Y, Govitrapong P, Morales NP, et al. Caffeine potentiates methamphetamine-induced toxicity both in vitro and in vivo. Neurosci Lett. 2011;502(1):65-9.
  • Saeaue L, Morales NP, Komalamisra N, Morales Vargas RE. Antioxidative systems defense against oxidative stress induced by blood meal in Aedes aegypti. Southeast Asian J Trop Med Public Health. 2011;42(3):542-9.
  • Limenta LM, Jirasomprasert T, Jittangprasert P, Wilairat P, Yamanont P, Chantharaksri U, Fucharoen S, Morales NP. Pharmacokinetics of deferiprone in patients with β-thalassaemia: impact of splenectomy and iron status. Clin Pharmacokinet. 2011;50(1):41-50.
  • Sutipornpalangkul W, Morales NP, Harnroongroj T. Free radicals in primary knee osteoarthritis. J Med Assoc Thai. 2009;92 Suppl 6:S268-74.
  • Sutipornpalangkul W, Morales NP, Charoencholvanich K, Harnroongroj T. Lipid peroxidation, glutathione, vitamin E, and antioxidant enzymes in synovial fluid from patients with osteoarthritis. Int J Rheum Dis. 2009;12(4):324-8.
  • Morales NP, Yamanont P, Jirasomprasert T, Wilairat P, Chantharaksri U, Chuncharunee S, et al. Bioequivalence study of a film-coated tablet of deferiprone in healthy Thai volunteers.Int J Clin Pharmacol Ther. 2009;47(5):358-64.
  • Jirasomprasert T, Morales NP, Limenta LM, Sirijaroonwong S, Yamanont P, Wilairat P, et al. Pharmaco/ferrokinetic-related pro-oxidant activity of deferiprone in β-thalassemia. Free Radic Res.  2009;43(5):485-91.
  • Tankanitlert J, Morales NP, Fucharoen P, Fucharoen S, Chantharaksri U. Association between promoter and coding region mutations of UDP-glucuronosyltransferase 1A1 and β-thalassemia/Hb E with cholelithiasis. Eur J Haematol. 2008;80(4):351-5.
  • Limenta LM, Jirasomprasert T, Tankanitlert J, Svasti S, Wilairat P, Chantharaksri U, Fucharoen S,Morales NP. UGT1A6 genotype-related pharmacokinetics of deferiprone (L1) in healthy volunteers. Br J Clin Pharmacol.  2008;65(6):908-16.
  • Chumark P, Khunawat P, Sanvarinda Y, Phornchirasilp S, Morales NP, Phivthong-Ngam L, et al. The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. J Ethnopharmacol. 2008;116(3):439-46.
  • Tankanitlert J, Morales NP, Howard TA, Fucharoen P, Ware RE, Fucharoen S, et al. Effects of combined UDP-glucuronosyltransferase (UGT) 1A1*28 and 1A6*2 on paracetamol pharmacokinetics in β-thalassemia/HbE. Pharmacology. 2007;79(2):97-103.
  • Somparn P, Phisalaphong C, Nakornchai S, Unchern S, Morales NP. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol Pharm Bull.  2007;30(1):74-8.
  • Tankanitlert J, Howard TA, Temsakulphong A, Sirankapracha P, Morales NP, Sanvarinda Y, et al. A pharmacokinetic study of paracetamol in Thai β-thalassemia/HbE patients. Eur J Clin Pharmacol. 2006;62(9):743-8.
  • Morales NP, Charlermchoung C, Luechapudiporn R, Yamanont P, Fucharoen S, Chantharaksri U. Lipid fluidity at different regions in LDL and HDL of β-thalassemia/Hb E patients. Biochem Biophys Res Commun.  2006;350(3):698-703.
  • Luechapudiporn R, Morales NP, Fucharoen S, Chantharaksri U. The reduction of cholesteryl linoleate in lipoproteins: an index of clinical severity in β-thalassemia/Hb E. Clinical chemistry and laboratory medicine : CCLM / FESCC. 2006;44(5):574-81.
  • Hirunpanich V, Utaipat A, Morales NP, Bunyapraphatsara N, Sato H, Herunsale A, et al. Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx ofHibiscus sabdariffa L. in hypercholesterolemic rats. J Ethnopharmacol. 2006;103(2):252-60.
  • Hirunpanich V, Utaipat A, Morales NP, Bunyapraphatsara N, Sato H, Herunsalee A, et al. Antioxidant effects of aqueous extracts from dried calyx of Hibiscus sabdariffa Linn. (Roselle) in vitro using rat low-density lipoprotein (LDL). Biol Pharm Bull. 2005;28(3):481-4.