Darawan Pinthong

ดาราวรรณ ปิ่นทอง

Chairperson
Associate Professor
+662-201-5641
+662-354-7157
darawan.pin@mahidol.edu
Education
  • Ph.D. (Pharmacology), Nottingham University, UK
  • M. Sc. (Pharmacology), Mahidol University, Thailand
  • B.Sc. (General Science), Chulalongkorn University, Thailand

 

Current Research
  • Receptor Pharmacology: characterization and signal transduction
  • Endocrine pharmacology
  • Pharmacology of medicinal plants
  • Pharmacogenomics
Publications
  • Saardpun N, Songsaeng R, Tanratana P, Kusamran T and Pinthong D*. The Finding of New In Vivo Metabolite Triptorelin (5-10) in Human Urine Using Liquid Chromatography Coupled with Ion Trap/Time-of-Flight Mass Spectrometry with Dimethyl Sulfoxide Additives in the Mobile Phase. Molecules 2023 Jun;28:4572.
  • Likitnukul S, Thammacharoen S, Sriwatananukulkit O, Duangtha C, Hemstapat R, Sunrat C, Mangmool S and Pinthong D*. Short-Term Growth Hormone Administration Mediates Hepatic Fatty Acid Uptake and De Novo Lipogenesis Gene Expression in Obese Rats. Biomedicines 2023 Mar;11(4):1050.
  • Likitnukul S*, Tepaamorndech S, Kaewamatawong T, Yangchum A, Duangtha C , Jongjang P, Mangmool S, Pinthong D, and Isaka M. Pyridylnidulin exerts anti-diabetic properties and improves nonalcoholic fatty liver disease in diet-induced obesity mice. Frontiers in Molecular Bioscience 2023 Jun 22; 10, 1208215.
  • Jampasri S, Reabroi S, Tungmunnithum D, Parichatikanond W, Pinthong D*. Plumbagin Suppresses Breast Cancer Progression by Downregulating HIF-1α Expression via a PI3K/Akt/mTOR Independent Pathway under Hypoxic Condition. Molecules, 2022, 27(17), 5716.
  • Tohkayomatee R, Reabroi S, Tungmunnithum D, Parichatikanond W, Pinthong D*. Andrographolide exhibits anticancer activity against breast cancer cells (MCF-7 and MDA-MB-231 cells) through suppressing cell proliferation and inducing cell apoptosis via inactivation of ER- receptor and PI3K/AKT/mTOR signaling. Molecules, 2022, 27(11), 3544.
  • Duangrat R, Parichatikanond W, Phumala Morales N, Pinthong D and Mangmool S. Sustained AT1R stimulation induces upregulation of growth factors in human cardiac fibroblasts via Gαq/TGF-β/ERK signaling that influences myocyte hypertrophy. European Journal of Pharmacology, Nov. 2022, 937:17538
  • Rodseeda C, Yamanont P, Pinthong D, Korprasertthaworn P. Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib. Toxicology Reports, 2022, 9,1846-1852.
  • Jantaratnotai N, Thampithak A, Utaisincharoen P, Pinthong D, Sanvarinda P. Inhibition of LPS-induced microglial activation by ethyl acetate extract of Pueraria mirifica. IJERPH 2022, 19(19), 12920.
  • Likitnukul S, Thammacharoen S, Kalandakanond-Thongsong S, Sriwatananukulkit O, Hemstapat R, Pinthong D. The Effect of the Short‐Term Growth Hormone Administration on Non‐Alcoholic Fatty Liver Disease in Diet‐Induced Obesity Models. The FASEB Journal. 2020; 34: 1-1. doi:10.1096/fasebj.2020.34.s1.02562
  • Tungmunnithum D, Pinthong D and Hano C. Flavonoids from Nelumbo nucifera Gaertn., a Medicinal Plant: Uses in Traditional Medicine, Phytochemistry and Pharmacological Activities. Medicines 2018, 5(4), 127
  • Wiriyakosol N, Puangpetch A, Manosuthi W, Tomongkon S, Sukasem C, Pinthong D*.  A LC/MS/MS method for determination of tenofovir in human plasma and its application to toxicity monitoring. Journal of Chromatography B. 2018 1085 : 89-95.
  • Sillapapongwarakorn S, Yanarojana S, Pinthong D, Thithapandha A, Ungwitayatorn J, Supavilai P. Molecular docking based screening of triterpenoids as potential G-quadurplex stabilizing ligands with anti-cancer activity. Bioinformation. 2017; 23(9): 284-292
  • Pongthanaracht N, Yanarojana S, Pinthong DUnchern SThithapandha AAssantachai PSupavilai P. Association between butyrylcholinesterase k variant and mild cognitive impairment in the Thai community-dwelling patients. Clinical Interventions in Aging 2017; 12:897-901.
  • Medhasi S, Pinthong D, Pasomsub E, Vanwong N, Ngamsamut N, Puangpetch A, Chamnanphon M, Hongkaew Y, Pratoomwun J, Limsila P, Sukasem C. Pharmacogenomic study reveals new variants of drug metabolizing enzyme and transporter genes associated with steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone in Thai autism spectrum disorder patients. Frontiers in Pharmacology. 2016;7:475.
  • Mangmool S, Denkaew T, Phosri S, Pinthong D, Parichatikanond W, Shimauchi T, Nishida M. Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner. Mol Endocrinol. 2016;30(1):118-32.
  • Medhasi S, Pasomsub E, Vanwong N, Ngamsamut N, Puangpetch A, Chamnanphon M, Hongkaew Y, Limsila P, Pinthong D, Sukasem C*. Clinically relevant genetic variants of drug-metabolizing enzyme and transporter genes detected in Thai children and adolescents with autism spectrum disorder. Neuropsychiatr Dis Treat. 2016;12:843-51.
  • Sensorn I, Sukasem C, Sirachainan E, Chamnanphon M, Pasomsub E, Trachu N, Supavilai P, Pinthong D*, Wongwaisayawan S*. ABCB1 and ABCC2 and the risk of distant metastasis in Thai breast cancer patients treated with tamoxifen. Onco Targets Ther. 2016;9:2121-9.
  • Sensorn I, Sirachainan E, Chamnanphon M, Pasomsub E, Trachu N, Supavilai P, Sukasem C, Pinthong D*. Association of CYP3A4/5, ABCB1 and ABCC2 polymorphisms and clinical outcomes of Thai breast cancer patients treated with tamoxifen. Pharmgenomics Pers Med. 2013;6:93-8.
  • Parichatikanond W, Pinthong D, Mangmool S. Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin. Planta medica. 2012;78(15):1626-32.
  • Boonyareth M, Saranak J, Pinthong D, Sanvarinda Y, Foster KW. Roles of cyclic AMP in regulation of phototaxis in chlamydomonas reinhardtii. Biologia. 2009;64(6):1058-65.
  • Pinthong D*, Songsermsakul P, Rattanachamnong P, Kendall DA. The effects of imidazoline agents on the aggregation of human platelets. J Pharm Pharmacol. 2004;56(2):213-20.
  • Pinthong D, Kendall DA, Wilson VG. Complex interaction of alpha(2)-adrenoceptor binding sites with bovine brain and lung extracts containing clonidine-displacing substance. Ann N Y Acad Sci. 2003;1009:216-21.
  • Pinthong D, Kendall DA, Maclennan SJ, Eglen RM, Wilson VG. No evidence for activation of alpha(2)-adrenoceptors by methanolic extracts of bovine brain and lung containing clonidine-displacing substance. Ann N Y Acad Sci. 2003;1009:201-15.
  • Pinthong D, Wright IK, Hanmer C, Millns P, Mason R, Kendall DA, et al. Agmatine recognizes alpha 2-adrenoceptor binding sites but neither activates nor inhibits alpha 2-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 1995;351(1):10-6.
  • Pinthong D, Hussain JF, Kendall DA, Wilson VG. Comparison of the interaction of agmatine and crude methanolic extracts of bovine lung and brain with alpha 2-adrenoceptor binding sites. Br J Pharmacol. 1995;115(4):689-95.
  • McGrath JC, Brown CM, Daly CJ, Kendall D, MacKinnon A, Miller DJ, Nagadeh M, O’Dowd A, O’Dowd JJ, Pinthong D, et al. The relationship between the adrenoceptor and nonadrenoceptor-mediated effects of imidazoline- and imidazole-containing compounds. Ann N Y Acad Sci. 1995;763:591-605.