Warinkarn (Kamondanai) Hemstapat

Assistant Professor
  • B.Sc. (Pharm) Rangsit University, Thailand
  • Ph.D. (Pharmacy) The University of Queensland, Australia
Current Research
  • Mechanism of osteoarthritis pain
  • Identifying alternative approaches for treating pain-associated with orthopedics conditions such as Osteoarthritis
  • Anti-inflammatory and analgesic properties of natural product-derived compounds
  • Tawonsawatruk T, Sriwatananukulkit O, Himakhun W, Hemstapat W. Comparison of pain behavior and osteoarthritis progression between anterior cruciate ligament transition and osteochondral injury in rat models. Bone Joint Res 2018;7:244–251
  • Soonthornsit N, Hemstapat W, Pitaksutheepong C,Pitaksuteepong T. Enhancement of stability, release and in vitro digestibility of mulberry stem extract using microemulsions. International Jounal of Pharmacy and Pharmaceutical Sciences. Vol 9, Issue 7, 2017
  • Soonthornsit N, Pitaksutheepong C, Hemstapat W, Utaisincharoen P, Pitaksuteepong T*. In vitro anti-inflammatory activity of Morus alba L. Stem extract in LPS-stimulated RAW 264.7 cells. Evid-based Complement Altern Med 2017;2017:3928956.
  • Pham PP, Morales NP, Pitaksuteepong T, Hemstapat W.Antioxidant activity of mulberry stem extract: Apotential used as supplement for oxidative stress-related diseases. Songklanakarin J. Sci. Technol. 39(3), 407-414, May-Jun.2017
  • Yatmark P, Morales NP, Chaisri U, Wichaiyo S, Hemstapat W, Srichairatanakool S, Svasti S, Fucharoen S. Iron distribution and histopathological study of the effects of deferoxamine and deferiprone in the kidneys of iron overloaded β-thalassemic mice. Exp Toxicol Pathol. 2016 Jul 8. pii: S0940-2993(16)30079-3. doi: 10.1016/j.etp.2016.06.006.
  • Suwanprateeb J, Luangwattanawilai T, Theeranattapong T, Suvannapruk W, Chumnanvej S, Hemstapat W. Bilayer oxidized regenerated cellulose/poly ε-caprolactone knitted fabric-reinforced composite for use as an artificial dural substitute. J Mater Sci Mater Med. 2016;27(7):122.
  • Khunakornvichaya A, Lekmeechai S, Pham PP, Himakoun W, Pitaksuteepong T, Morales NP, Hemstapat WMorus alba L. stem extract attenuates pain and articular cartilage dmage in the anterior cruciate ligament transection-induced rat model of osteoarthritis. Pharmacology. 2016;98(5-6):209-216.
  • Yatmark P, Morales NP, Chaisri U, Wichaiyo S, Hemstapat W, Srichairatanakool S, et al. Iron distribution and histopathological characterization of the liver and heart of β-thalassemic mice with parenteral iron overload: Effects of deferoxamine and deferiprone. Exp Toxicol Pathol. 2014;66(7):333-43.
  • Grumbles RM, Almeida VW, Casella GT, Wood PM, Hemstapat K, Thomas CK. Motoneuron replacement for reinnervation of skeletal muscle in adult rats. J Neuropathol Exp Neurol. 2012;71(10):921-30.
  • Alagille D, DaCosta H, Chen Y, Hemstapat K, Rodriguez A, Baldwin RM, et al. Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series. Bioorg Med Chem Lett. 2011;21(11):3243-7.
  • Hemstapat K, Le L, Edwards SR, Smith MT. Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A(2-17) following spinal and supraspinal routes of administration. Pharmacol Biochem Behav. 2009;93(4):498-505.
  • Hemstapat K, Da Costa H, Nong Y, Brady AE, Luo Q, Niswender CM, et al. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007;322(1):254-64.
  • Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP, et al. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol Pharmacol. 2007;71(5):1389-98.
  • Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, et al. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol Pharmacol. 2006;70(2):616-26.
  • Galici R, Jones CK, Hemstapat K, Nong Y, Echemendia NG, Williams LC, et al. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol Exp Ther. 2006;318(1):173-85.
  • de Paulis T, Hemstapat K, Chen Y, Zhang Y, Saleh S, Alagille D, et al. Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes. J Med Chem. 2006;49(11):3332-44.
  • Hemstapat K, Smith MT, Monteith GR. Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: potential application to biomolecular screening. J Pharmacol Toxicol Methods. 2004;49(2):81-7.
  • Hemstapat K, Smith SA, Monteith GR, Smith MT. The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones. Pharmacol Toxicol. 2003;93(4):197-200.
  • Hemstapat K, Monteith GR, Smith D, Smith MT. Morphine-3-glucuronide’s neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: mechanistic studies in embryonic cultured hippocampal neurones. Anesth Analg. 2003;97(2):494-505.